Masuo Kondoh Selected Research

Claudins

11/2020	Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model.
1/2020	Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
10/2017	Development of a Quenchbody for the Detection and Imaging of the Cancer-Related Tight-Junction-Associated Membrane Protein Claudin.
1/2017	Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers.
1/2017	Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.
12/2015	Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.
10/2014	Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy.
2/2014	Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin.
8/2010	A claudin-targeting molecule as an inhibitor of tumor metastasis.
6/2010	Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin.

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Masuo Kondoh Research Topics

Disease

36	Neoplasms (Cancer) 06/2022 - 08/2004
11	Infections 01/2022 - 11/2006
10	Leukemia 11/2005 - 01/2002
6	Neoplasm Metastasis (Metastasis) 08/2020 - 08/2010
4	Body Weight (Weight, Body) 01/2022 - 08/2009
4	Inflammation (Inflammations) 10/2021 - 03/2018
4	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 12/2015
3	Carcinoma (Carcinomatosis) 06/2022 - 01/2006
3	Breast Neoplasms (Breast Cancer) 11/2020 - 01/2006
3	Foodborne Diseases 01/2020 - 01/2018
3	Fibrosis (Cirrhosis) 01/2010 - 02/2008
3	Liver Cirrhosis (Hepatic Cirrhosis) 05/2008 - 01/2008
2	Endometrial Neoplasms (Endometrial Cancer) 01/2021 - 01/2020
2	Squamous Cell Carcinoma of Head and Neck 05/2020 - 01/2020
2	Virus Diseases (Viral Diseases) 01/2019 - 01/2013
2	Carcinogenesis 05/2018 - 10/2004
2	Hepatitis 03/2018 - 01/2017
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 03/2018 - 06/2015
2	Necrosis 03/2010 - 05/2004
2	Liver Diseases (Liver Disease) 05/2008 - 11/2006
1	Allergic Rhinitis 08/2021
1	Rhinosinusitis 08/2021
1	Renal Cell Carcinoma (Grawitz Tumor) 11/2020
1	Colorectal Neoplasms (Colorectal Cancer) 08/2020
1	Diabetes Mellitus 08/2020
1	Colonic Neoplasms (Colon Cancer) 08/2020
1	Polyps 05/2020
1	Adenoma (Adenomas) 05/2020
1	Nervous System Diseases (Neurological Disorders) 10/2018
1	Fibrosarcoma 05/2018
1	Hyperkalemia 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 10/2016

Drug/Important Bio-Agent (IBA)

13	Claudin-4IBA 06/2022 - 01/2006
12	ClaudinsIBA 11/2020 - 01/2006
9	Monoclonal AntibodiesIBA 01/2021 - 10/2014
8	Proteins (Proteins, Gene)FDA Link 06/2022 - 01/2016
8	Tight Junction ProteinsIBA 01/2021 - 06/2010
7	Clostridium enterotoxinIBA 05/2020 - 02/2014
7	Pharmaceutical PreparationsIBA 01/2019 - 09/2009
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2008
6	DiterpenesIBA 11/2005 - 10/2003
6	Kaurane DiterpenesIBA 11/2005 - 10/2003
5	VaccinesIBA 08/2019 - 07/2012
5	CaspasesIBA 04/2005 - 01/2002
4	OccludinIBA 01/2021 - 05/2016
4	Claudin-1IBA 12/2016 - 04/2015
4	Antineoplastic Agents (Antineoplastics)IBA 10/2016 - 08/2004
3	AntigensIBA 01/2021 - 01/2012
3	Immunoglobulin Fab FragmentsIBA 01/2021 - 04/2015
2	DNA (Deoxyribonucleic Acid)IBA 06/2022 - 05/2004
2	LigandsIBA 01/2021 - 06/2010
2	AntibodiesIBA 01/2021 - 10/2014
2	Peptides (Polypeptides)IBA 12/2020 - 01/2020
2	Insulin (Novolin)FDA Link 08/2020 - 10/2016
2	Amino Acids FDA Link 01/2020 - 01/2017
2	angubindin-1IBA 01/2020 - 10/2018
2	Immunoglobulin G (IgG)IBA 12/2016 - 04/2015
2	Cysteine (L-Cysteine)FDA Link 05/2016 - 02/2003
2	Alanine Transaminase (SGPT)IBA 03/2010 - 05/2008
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 03/2010 - 05/2008
2	Transaminases (Aminotransferases)IBA 08/2009 - 01/2008
2	Ganciclovir (Cytovene)FDA LinkGeneric 10/2008 - 10/2008
2	Thymidine KinaseIBA 10/2008 - 10/2008
2	A-130A (A 130)IBA 10/2008 - 10/2008
2	Biological ProductsIBA 02/2008 - 11/2005
2	pyrithioneIBA 04/2005 - 12/2002
2	IonophoresIBA 04/2005 - 12/2002
2	Caspase 3 (Caspase-3)IBA 05/2004 - 02/2003
1	Disinfectants (Biocides)IBA 01/2022
1	Coloring Agents (Dyes)IBA 10/2021
1	HMGB1 Protein (HMG1)IBA 08/2021
1	Single-Chain AntibodiesIBA 01/2021
1	SugarsIBA 08/2020
1	Hemoglobins (Hemoglobin)IBA 08/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 08/2020
1	BiglycanIBA 08/2020
1	Cadherins (E-Cadherin)IBA 05/2020
1	Diphosphonates (Bisphosphonates)IBA 05/2020
1	Tamoxifen FDA LinkGeneric 05/2020
1	Lipoprotein Receptors (Lipoprotein Receptor)IBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	ImmunosorbentsIBA 05/2019
1	EnzymesIBA 05/2019
1	Shiga Toxin (Shigella Toxin)IBA 01/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Shiga Toxin 2IBA 01/2019
1	Growth Factor ReceptorsIBA 12/2018
1	Fluorouracil (Carac)FDA LinkGeneric 12/2018
1	Cetuximab (Erbitux)FDA Link 12/2018
1	Antisense OligonucleotidesIBA 10/2018
1	Claudin-2IBA 05/2018
1	Food IngredientsIBA 03/2018
1	AcidsIBA 03/2018
1	Combined VaccinesIBA 01/2018
1	Cholera ToxinIBA 01/2018
1	Membrane Proteins (Integral Membrane Proteins)IBA 10/2017

Therapy/Procedure

21	Therapeutics 01/2020 - 01/2006
2	Intravenous Injections 11/2020 - 05/2018
2	Drug Therapy (Chemotherapy) 12/2015 - 10/2004
2	Transplantation 05/2008 - 01/2008